What is CBDA?
CBDA stands for cannabidiolic acid, and as the name suggests, this molecule is closely related to CBD. In fact, CBDA can be considered the parent molecule of CBD as it is present in raw cannabis, whereas CBD is only created through the process of decarboxylation.
CBDA is what is known as a carboxylic acid, meaning that its structure contains a carboxyl group comprising one carbon, one hydrogen, and two oxygen atoms, commonly expressed as COOH. When this molecule is exposed to high temperatures, this group breaks up to form carbon dioxide and hydrogen. What you are left with is CBD, or cannabidiol to give it its proper name. This reaction is known as decarboxylation, and although to some extent it happens naturally over time, the process is extremely slow.
What is the Difference Between CBD and CBDA?
The chemical structures of CBD and CBDA are incredibly similar. The only difference is that CBDA contains the extra COOH group which is removed by decarboxylation. It is widely believed that CBD is more biologically active than CBDA, and it is undoubtedly more popular when it comes to health products and supplements. However, CBDA is by no means completely inert.
The main difference here is that while there are countless research papers published on CBD and its benefits, scientific studies on CBDA are sadly lacking. So is CBDA really less effective than CBD, or is it just misunderstood? Let’s review the available research on CBDA and assess its possible benefits for our health.
There has not been much research published on CBDA to date, especially when compared to its relatives CBD and THC. However, according to the few studies that have been carried out into the effects of CBDA, it shows remarkable promise in the treatment of several conditions.
CBDA for Cancer
One of the conditions for which CBDA is offering hope is cancer, specifically breast cancer. Studies by Takeda et al. found that CBDA has the potential to suppress breast cancer cells and inhibit them from spreading throughout the body, a process known as metastasis.
The researchers found that exposing cancer cells to CBDA for just 48 hours downregulated the expression of an enzyme called cyclooxygenase-2 (COX-2). This enzyme is involved in the inflammatory process, and is thought to play a role in as many as 40% of cases of invasive breast cancer. In addition, CBDA appeared to upregulate a gene called SHARP1 (also known as BHLHE41), which has the action of inhibiting breast cancer metastasis.
Since metastasis is estimated to be responsible for up to 90% of the deaths related to breast cancer, this finding could prove vital in improving the prognosis for patients diagnosed with this life-threatening condition.
CBDA for Inflammatory Conditions
Since CBDA has been shown to inhibit COX-2, it will have anti-inflammatory properties, much like the better-known cannabinoid CBD. Many conventional anti-inflammatory drugs work by inhibiting COX-2, and these are commonly used in the treatment of painful conditions such as arthritis.
Although, at present, no studies have been carried out specifically on CBDA for joint pain or arthritis, we can hypothesize that it should offer some relief. It is thought that the COOH component of the molecule is critical in specifically targeting COX-2, and CBDA may even be more effective than THC in its anti-inflammatory effects.
CBDA for Nausea and Vomiting
One area where CBDA has been well researched is in the treatment of nausea and vomiting. A study conducted by Bolognini et al. found that CBDA effectively relieved toxin and motion-induced vomiting in shrews, and reduced nausea in rats. Most significantly, these scientists suggest that CBDA could reduce nausea and vomiting even more effectively than CBD.
It appears that these potent effects are produced as a result of CBDA enhancing the activation of 5-HT1A receptors. These receptors are designed to bind with the neurotransmitter serotonin, and are found in high concentrations in the digestive system. The researchers also suggested that CBDA may influence the endocannabinoid system directly by binding with CB1 receptors in the nervous system.
More research is definitely needed to establish the effects of CBDA on nausea and vomiting in humans, but if proven, this treatment could offer relief to patients suffering from the side effects of chemotherapy as well as nausea related to other conditions.
CBDA for Mental Wellbeing
There is little evidence currently available to support this use of CBDA, but it has been suggested that this compound could be useful in the treatment of stress and anxiety. One company has even taken out a patent on CBDA and other cannabinoids as a therapy when combined with antipsychotic medication.
Is CBDA Legal?
The good news is that since CBDA has no psychoactive properties, it is legal in most places around the world. However, this relies on CBDA being sourced from hemp with less than 0.3% THC rather than other cannabis varieties. All CTFO Hemp Oil are 100% legal in all 50 states. Our products are made from hemp plants, not marijuana plants.
One caveat is that due to the lack of research, CBDA is classed as a food supplement rather than a medicine. As such, it is not strictly regulated, so if you decide to try a product containing CBDA, make sure you buy it from a reputable source, preferably one which uses third-party lab testing. That way you will know that you are getting a high-quality product, and exactly how much CBDA should be in each dose.
CTFO owns the exclusive world-wide distribution rights to our parented 10X Pure process. Our patented processes enables us to protect the CBDA so it can be assimilated by the our bodies. 10X Pure also produces significantly more potency which enables us to provide a leading edge CBD product at an amazing price!
Activating the endocannabinoid system has many positive results. The use of CBD has been known to have many physical benefits such as:
Supports healthy blood sugar levels
Joint pain relief
Promotes healthy energy levels
Aids in digestion
Promotes overall feelings of serenity and well-being
Supports optimal immune function
Supports the regeneration of healthy cells.
Did you know CBD isn't just for ingestion?
It also has amazing benefits for your skin when used topically. Our assortment of hemp CBD anti-aging hair growth products are designed to help your skin and hair look and feel incredible! Use to promote firmer skin, each product in our skincare line contains 20mg of CBD, this helps stimulate natural collagen production, elastin production, and also can reduce age lines and brighten dullness or age spots.
Our hemp CBD hair growth products contain patented AnaGain. AnaGain stimulates specific signal molecules in the hair to reactivate and promote hair growth. AnaGain combined with 50mg of CBD per container helps to give your hair the nourishment and stimulation needed to grow fuller and thicker!
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According to Forbes, the hemp CBD (cannabidiol) market is going to become the next billion dollar industry and will grow by a staggering 700% in the next couple of years. By 2026 the cannabis industry is projected to be at $50 billion and a good portion of that will be due to hemp oil products. A new estimate from cannabis industry analysts the Brightfield Group, says this market alone could hit $22 billion by 2022.
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